Purpose of the Test:
This test aids in diagnosing gluten sensitivity in patients with symptoms indicative of this condition, helping to identify individuals who may benefit from a gluten-free diet.
Target Population:
Recommended for both children and adults with suspected gluten sensitivity.
What is Gluten?
Gluten is a protein present in wheat, rye, and barley. Gliadin, a component of gluten, contains most of its toxic elements and is resistant to breakdown in the upper gastrointestinal tract, allowing it to penetrate the intestinal barrier.
Understanding Gluten Sensitivity:
Gluten sensitivity represents a heightened immune response to gluten ingestion. It can manifest as:
- Enteropathy (e.g., celiac disease)
- Dermatopathy (e.g., dermatitis herpetiformis)
- Neurological disorders (e.g., ataxia, neuropathy)
- Various nonspecific symptoms, including:
- Anemia
- Chronic fatigue
- Joint inflammation and pain
- Migraines
- Depression
- Attention-deficit disorder
- Epilepsy
- Osteoporosis and osteopenia
- Infertility and recurrent fetal loss
- Vitamin deficiencies
- Delayed puberty and dental enamel defects
- Autoimmune disorders
Prevalence and Mortality:
Gluten sensitivity affects up to 12% of the general population and is associated with increased mortality rates.
Antibody Testing:
- The test detects antibodies to deamidated gliadin peptides and tissue transglutaminase, which are specific to celiac disease.
- Antibodies to native gliadin indicate gluten sensitivity and may be present in patients regardless of gastrointestinal symptoms.
- Some individuals may also experience allergic reactions to gluten-containing foods, such as wheat.
Clinical Use:
This screening profile assists healthcare providers in diagnosing various forms of gluten sensitivity, guiding appropriate dietary recommendations and interventions for affected individuals.
Why would I need a Gluten Sensitivity Test?
Gastrointestinal issues: Such as abdominal pain, bloating, diarrhea, constipation, or weight loss.
Non-digestive symptoms: These include fatigue, joint pain, headaches, skin rashes (e.g., dermatitis herpetiformis), and neurological symptoms like tingling or numbness.
Family history: If you have a close relative with celiac disease or gluten sensitivity, you may be at a higher risk and advised to get tested.
Unexplained nutrient deficiencies, Such as iron deficiency anemia, can result from damage to the small intestine caused by gluten.
Monitoring celiac disease: If you have been diagnosed with celiac disease, this test may help monitor adherence to a gluten-free diet and assess the presence of antibodies.
How do I prepare for a Gluten Sensitivity Test?
Proper preparation is important to obtain accurate results:
Consume gluten: You must consume gluten-containing foods (such as wheat, barley, and rye) for several weeks before the test to ensure your immune system is exposed and, if you have gluten sensitivity or celiac disease, is producing antibodies. Avoiding gluten before the test may lead to false-negative results.
No fasting required: Fasting is not necessary for this test. You can eat and drink as usual before the test.
Medication disclosure: Inform your healthcare provider of any medications you take, as certain immunosuppressive drugs may affect the results.